{"id":7531,"date":"2020-10-12T11:33:01","date_gmt":"2020-10-12T03:33:01","guid":{"rendered":"https:\/\/nutritional-humility.me\/oxystaging\/?p=7531"},"modified":"2022-12-18T15:15:42","modified_gmt":"2022-12-18T07:15:42","slug":"updates-to-the-glycation-end-products-manuscript-v1-03","status":"publish","type":"post","link":"https:\/\/nutritional-humility.me\/oxystaging\/updates-to-the-glycation-end-products-manuscript-v1-03\/","title":{"rendered":"Updates to the Glycation End Products Manuscript (V1.03)"},"content":{"rendered":"

Download the latest iteration here.<\/a><\/p>\n

What' new? Version 1.03<\/h1>\n

1\/2<\/h2>\n

Re-adapted flowchart of AGEs formation \/ Entirely new Overview<\/h3>\n

So far, enlightening for lay readers the mechanistic origins of Glycation End Products ~ have been a very difficult task.\u00a0Considering the numerous pathways, models, or mechanisms sharing many confusing interrelationships from one to another.<\/p>\n

Whilst working on the next book<\/a> ~ I have taken the time (patiently) revisiting these subjects. Discerning any similarities between the various models, mechanisms or pathways. Though admittedly not all \u00ac due to limited indemnity and comprehension. Please acquaint yourselves with the professional indemnity declaration subsection<\/strong>.<\/p>\n

After much reading I shortlisted down to just three (3) sample model pathways on where<\/strong> and how<\/strong> Glycation products may be initiated, through:<\/p>\n

    \n
  1. Maillard Reaction <\/strong>(concerning sugars+amino acid), <\/strong><\/li>\n
  2. Poly-OL<\/strong> (concerning exclusively fructose),\u00a0<\/strong><\/li>\n
  3. ....and Lipid Peroxidation <\/strong>(concerning exclusively fatty acids).\u00a0<\/strong><\/li>\n<\/ol>\n

    Why \"only\"<\/strong> three (3)? I believe basing them from three macronutrients<\/strong> ~ is easier for anyone to relate to as an introduction. Allowing them to start \"broadly then deeply specific\"<\/strong>\u00a0acquainting with this complex subject.<\/p>\n

    Rather than diving straight specifically<\/strong><\/em> into dozens of model pathways yet forgoing the \"bigger picture\"<\/strong>. There's Heyn Products<\/a>. Before then ~ \"Hexosamine<\/a>\" Pathway, \u00a0\"Namiki\"<\/a> Pathway, \"Wolff<\/a>\" Pathway, \"Hodge<\/a>\" Pathway, and the\u00a0\"Bacterial\"<\/a> pathway; all these remains yet to be comprehensible in plain language.<\/p>\n

    \"The

    The 3 sample pathways; re-adapted diagram<\/p><\/div>\n

    I have designed a\u00a0flowchart to accommodate the above three models.<\/strong><\/p><\/blockquote>\n

    As re-adapted\u00a0 from existing research in willingly concordance to Creative Commons (<\/strong>Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0).<\/i><\/b><\/p>\n

    2\/2<\/h2>\n

    New subsection \"Is Glycation a flaw or feature ~ of biology?\" Info on salt intakes<\/h3>\n

    Oxidation and Antioxidation mechanisms is part of Glycation, nonetheless. Inevitably ~ accepting this as \"reality\" is difficult enough for splitting hairs.<\/p>\n

    I have therefore written an \"assurance\" section under the Further Discussion<\/strong> chapter. To hypothesise whilst there is much more that we \"do not know\" ~ we \"can\"<\/strong>\u00a0remain humble to accept<\/strong> that Nature is never black and white.<\/strong><\/p>\n

    In addition a small subsection on salt. It may yet seem trivial and frivolous topic but surprisingly there is little if any ~ findings on how salt impacts on Glycation. Here I propose various hypothesis from however few literature\/s mentioning these to date.<\/p>\n

     <\/p>\n

    Thank you + Disclaimer recite.<\/h2>\n

    As however \"minor\" update this post implies ~ this took a near full month<\/strong><\/span> writing, reading, and line-by-line critique round the clock, amidst structural hardships<\/a>.<\/p>\n

    I shall remind once more that this accompanying technical manuscript is completely independent, personal initiative and intended only to introduce surface dialogues to the complex concerns of Glycation in lay, pragmatic language freely available for all. It is never meant to replace existing literatures. I appreciate your thoughts and feedbacks.<\/p>\n

    Live-It-Forward,<\/p>\n

    AW™.<\/p>\n","protected":false},"excerpt":{"rendered":"

    These updates (V1.03) introduce a surface discussion surrounding the where and how Glycation\u00a0manifests towards their \"Advanced\" or the \"End\"\/Final stage of oxidation products.<\/p>\n","protected":false},"author":1,"featured_media":7550,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/o7u3ja.sn.files.1drv.com\/y4mrD6Kz1Y6NYdDEpmUXgg0OvIGNvieYxmRU6Cy9aQXbrt6fftaqT4F-sO7tXkW4KT68y1nYftY1Gs-DkKKZYTvhjfeSNJwqgO2m7ytqCBat0ZFeqD9cR7B8pRKiI-BO2prowSRsy5o7OZeYt1szSSLNClfz0EOHlT90ZdkQfAaNyZ2GsB-BaoyMkDKuWfrRSnrAxIKx_AnQiZzRJNbwWaoMA?width=561&height=794&cropmode=none","fifu_image_alt":"Updates to the Glycation End Products Manuscript (V1.03)","footnotes":""},"categories":[8,3,10,36,4],"tags":[],"class_list":["post-7531","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-announcements","category-insights","category-methods","category-start-here","category-thoughts"],"yoast_head":"\nUpdates to the Glycation End Products Manuscript (V1.03) - 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